Digitization is changing the face of the media and entertainment (M&E) industry across the globe. We live in a networked world, where geographical boundaries are giving way to globalization. The influencer, the gamer, the streamer, and the viewer are all part of this constantly evolving ecosystem and help determine the potential growth of the industry. Safeguarding the interests of all connected customers is crucial, as the industry deals with several threats that not only weigh down revenue and reputation but also accessibility, user privacy and security, and social and communal harmony. In this paper, we talk about the business and managerial challenges of this industry, with a specific focus on trust and safety (T&S), and how enterprises and service providers are coming together to maintain the integrity of M&E.